Study of gene patterns for Rifampicin in LPA, which were discordant in CBNAAT in the state of Telangana, India

Introduction: Among the first line drugs used for treatment of Drug Sensitive Tuberculosis, Rifampicin plays a crucial role. Hence it is important to know resistance using molecular technologies like CBNAAT and probe Assay. However, diagnostic dilemma occurs when there discordance in result rifampicin at periphery higher laboratories Intermediate Reference Laboratory (IRL). Aims objectives: To study various patterns Gene that demonstrated probes Line Probe Assao First –Line Assay, which showed with periphery. Methodology: A retrospective observational was conducted from 1st January 2021 31st December all those samples discordance. Result: total 203 results were found discordant Rifampicin. The resolution resolved NAAT facility Most occurred concurrence field. Eight them gave inconclusive (MTB not detected) Conclusion: It very understand gene LPA providing appropriate regimen patients.